METHYLENE BLUE
£25.00 – £66.50
Introduction and Benefits
Methylene Blue (MB), with the molecular formula C₁₆H₁₈ClN₃S·3H₂O, was the first fully synthetic drug, formulated in 1876. Initially a dye, it became a medical tool for treating conditions like cyanide poisoning and urinary tract infections. Current research highlights its broad health benefits, including improved mitochondrial and cognitive health, delayed cellular ageing, and antioxidant properties.
MB enhances mitochondrial efficiency, significantly increasing cellular oxygen consumption by 37–70%, and has demonstrated notable anti-inflammatory, anti-ageing, and neuroprotective effects.
Applications
Mitochondrial and Cognitive Health
- Delays cellular senescence and enhances mitochondrial biochemical pathways.
- Effective in Alzheimer’s disease (AD) by improving mitochondrial respiration, reducing amyloid deposition, and increasing acetylcholine levels.
- Promotes neuroprotection during cardiac arrest-induced oxygen deprivation.
Antiviral Properties
- Exhibits activity against SARS-CoV, Epstein-Barr, herpes, influenza, Ebola, and others.
- Preventive role noted in a cohort of cancer patients with no SARS-CoV-2 cases.
Cancer and Photodynamic Therapy
- Induces cancer cell apoptosis via oxidative stress.
- Used in photodynamic therapy for tumours, leishmaniasis, and drug-resistant psoriasis.
Skin Health
- Enhances collagen and elastin production, promoting skin vitality.
Psychiatric Applications
- As a monoamine oxidase inhibitor (MAOI), MB addresses depression by modulating serotonin and noradrenaline.
Other Clinical Uses
- Treats methemoglobinemia, malaria, septic shock, and poisonings like cyanide
Dosing and Safety
Low concentrations (<2.5 μM) are most effective, with a starting point of 0.5 μM for safety. Doses >5 mg/kg risk serotonin toxicity. MB is contraindicated with SSRIs, SNRIs, MAOIs, and in pregnancy or renal impairment. Common drug interactions include antidepressants, immunosuppressants, and cardiac medications.
Key Studies and References
- Mitochondrial Protection: PubMed #17928358.
- Neuroprotection in Alzheimer’s: PubMed #20463399.
- Cardiac Arrest Protection: PMC #2904268.
- Cancer Study: French Cancer Cohort.
- Antiviral Activity: Nature Study.
If you are on prescription drugs please check whether they are compatible with Methylene Blue. By using the drug interaction checker by drugs.com.
Disclaimer: by using Methylene Blue or any other product on this site you agree to the terms and conditions outlined in our legal medical disclaimer.